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Related Experiment Video

Updated: Jul 4, 2026

Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

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Published on: December 24, 2015

Challenge for a better combination with basic evidence.

Kazuhiro Yoshida1, Kazuya Yamaguchi, Shinji Osada

  • 1Department of Surgical Oncology, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. kyoshida@gifu-u.ac.jp

International Journal of Clinical Oncology
|June 17, 2008
PubMed
Summary

The combination of S-1 and docetaxel shows promise as a new standard treatment for metastatic gastric cancer, with a 56.3% response rate. Further phase III trials are ongoing to confirm its efficacy.

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Area of Science:

  • Oncology
  • Gastrointestinal Oncology
  • Chemotherapy

Background:

  • 5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent.
  • A standard first-line regimen for metastatic gastric cancer was not previously established.
  • Biochemical modulation of 5-FU and S-1 efficacy is an area of recent interest.

Purpose of the Study:

  • To evaluate the efficacy of S-1 and docetaxel combination therapy for metastatic gastric cancer.
  • To identify potential new standard regimens for advanced gastric cancer.
  • To investigate the role of docetaxel in modulating enzyme activities related to 5-FU metabolism.

Main Methods:

  • A phase II study evaluated the response rate and survival time of metastatic gastric cancer patients treated with S-1 and docetaxel.
  • Ongoing phase III START trial (S-1 and Taxotere for advanced gastric cancer randomized phase III trial) in Japan and Korea.

Main Results:

  • The combination therapy of docetaxel and S-1 demonstrated a response rate of 56.3% in a phase II study.
  • The median survival time for patients receiving S-1 and docetaxel was 14.3 months.
  • Low dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS) activities, and high orotate phosphoribosyl-transferase (OPRT) activity enhance antitumor effects.

Conclusions:

  • The combination of S-1 and docetaxel is a strong candidate for a new standard regimen for metastatic gastric cancer.
  • Biochemical modulation, including agents like docetaxel, can enhance the efficacy of chemotherapy.
  • Further validation through phase III trials like START is crucial.