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Updated: Jul 4, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Multiobjective immune algorithm with nondominated neighbor-based selection
Maoguo Gong1, Licheng Jiao, Haifeng Du
1Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China, Institute of Intelligent Information Processing, Xidian University, Xi'an, China. gong@ieee.org
Abstract:
Abstract Nondominated Neighbor Immune Algorithm (NNIA) is proposed for multiobjective optimization by using a novel nondominated neighbor-based selection technique, an immune inspired operator, two heuristic search operators, and elitism. The unique selection technique of NNIA only selects minority isolated nondominated individuals in the population. The selected individuals are then cloned proportionally to their crowding-distance values before heuristic search. By using the nondominated neighbor-based selection and proportional cloning, NNIA pays more attention to the less-crowded regions of the current trade-off front. We compare NNIA with NSGA-II, SPEA2, PESA-II, and MISA in solving five DTLZ problems, five ZDT problems, and three low-dimensional problems. The statistical analysis based on three performance metrics including the coverage of two sets, the convergence metric, and the spacing, show that the unique selection method is effective, and NNIA is an effective algorithm for solving multiobjective optimization problems. The empirical study on NNIA's scalability with respect to the number of objectives shows that the new algorithm scales well along the number of objectives.
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