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Updated: Jul 4, 2026

Quantifying the Binding Interactions Between Cu(II) and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
Designed metal-binding sites in biomolecular and bioinorganic interactions
Jacqueline M Matthews1, Fionna E Loughlin, Joel P Mackay
1School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia. j.matthews@usyd.edu.au
Abstract:
The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we review several developing areas of metal-related protein design, including the use of metals to induce protein-protein interactions or facilitate the assembly of extended nanostructures; the design of metallopeptides that bind metal and other inorganic surfaces, an area with potential in diverse applications ranging from nanoelectronics and photonics to biotechnology and biomedicine; and, the creation of sensitive and selective metal sensors for use both in vivo and in vitro.
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