Renal transplantation in primary focal segmental glomerulosclerosis using a tolerance induction protocol

Area of Science:

• Nephrology
• Immunology
• Transplantation Science

Background:

• Primary focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease recurrence post-transplantation.
• Graft loss due to FSGS recurrence significantly impacts patient outcomes.

Purpose of the Study:

• To evaluate the efficacy of the Ahmedabad Tolerance Induction Protocol (ATIP) in preventing FSGS recurrence after kidney transplantation.
• To compare outcomes of ATIP with standard immunosuppression in FSGS patients.

Main Methods:

• Retrospective analysis of 24 primary FSGS patients undergoing transplantation.
• 15 patients received ATIP with hematopoietic stem cell transplantation (HSCT) and minimal conditioning.
• 9 control patients received standard immunosuppression.

Main Results:

• No FSGS recurrence was observed in the 12 ATIP patients with available follow-up data.
• ATIP patients maintained favorable serum creatinine levels.
• Control group experienced significant FSGS recurrence (4/9 patients) and graft loss.

Conclusions:

• ATIP appears to be an effective strategy for mitigating FSGS recurrence post-transplantation.
• This protocol offers a potential solution to improve long-term graft survival in FSGS patients.