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Azoospermia after treatment with clomiphene citrate in patients with oligospermia
Fabio Firmbach Pasqualotto1, Gabriela Poglia Fonseca, Eleonora Bedin Pasqualotto
1Centro de Ciências Biológicas e da Saúde, Universidade de Caxias do Sul, and CONCEPTION, Center for Human Reproduction, Caxias do Sul, RS, Brazil. Fabio@conception-rs.com.br
Objective:
To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake.
Design:
Case report.
Setting(S):
Academic medical center.
Patient(S):
Three patients with oligospermia.
Intervention(S):
Three oligospermic men used CC, resulting in azoospermia.
Main Outcome Measure(S):
Semen analysis after CC use and after discontinuation of CC.
Result(S):
Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL.
Conclusion(S):
The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.
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