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A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities
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Heterogeneous one-dimensional model for fixed bed enzyme reactors.

R Lortie1, D Thomas

  • 1Laboratoire de Technologie Enzymatique, U.A. 523 du CNRS, Université de Technologie de Compiègne, BP 233, 60206 Compiègne, France.

Biotechnology and Bioengineering
|August 1, 1986
PubMed
Summary
This summary is machine-generated.

A new one-dimensional model describes fixed bed enzyme reactors, considering substrate diffusion. Numerical methods and nonlinear regression determined key parameters for various systems.

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Area of Science:

  • Chemical Engineering
  • Biochemical Engineering
  • Reaction Engineering

Background:

  • Fixed bed enzyme reactors are crucial in biochemical processes.
  • Understanding substrate diffusion is vital for reactor efficiency.
  • Existing models may not fully capture diffusion dynamics.

Purpose of the Study:

  • To develop and validate a one-dimensional model for fixed bed enzyme reactors.
  • To incorporate substrate diffusion between liquid and solid phases.
  • To determine model parameters using numerical and regression techniques.

Main Methods:

  • Development of a one-dimensional mathematical model.
  • Numerical solution of the model equations.
  • Application of nonlinear regression for parameter estimation.
  • Testing the model on diverse experimental systems.

Main Results:

  • The model successfully describes fixed bed enzyme reactor behavior.
  • Substrate diffusion significantly impacts reactor performance.
  • Accurate parameter values were obtained for tested systems.
  • Model predictions align well with experimental observations.

Conclusions:

  • The proposed one-dimensional model provides a robust framework for analyzing fixed bed enzyme reactors.
  • Accounting for substrate diffusion enhances model accuracy.
  • The methodology is applicable to various enzyme-substrate systems.