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Deactivation theory.

J P Henley1, A Sadana

  • 1Chemical Engineering Department, University of Mississippi, University, Mississippi 38677, USA.

Biotechnology and Bioengineering
|August 1, 1986
PubMed
Summary
This summary is machine-generated.

A general model for enzyme deactivation was developed. This model helps determine the number of active enzyme forms and can express parameters using physical constants for unimolecular processes.

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Area of Science:

  • Biochemistry
  • Enzyme Kinetics
  • Biophysical Chemistry

Background:

  • Enzyme deactivation is a critical factor in enzyme stability and function.
  • Understanding deactivation mechanisms is essential for enzyme applications and research.
  • Existing models may not fully capture the complexity of enzyme deactivation pathways.

Purpose of the Study:

  • To introduce a general mathematical model for enzyme deactivation.
  • To establish relationships between model parameters and physical constants.
  • To determine the number of independent, potentially active enzyme forms during deactivation.

Main Methods:

  • Development of a general mathematical model for unimolecular enzyme deactivation.
  • Analysis of parameter identifiability from deactivation data.
  • Discussion of strategies for handling excess physical parameters (independent analysis, lumped/global parameters).

Main Results:

  • The general model's parameters can often be expressed in terms of physical parameters.
  • The number of determinable physical parameters is limited by the number of independent constants in the model.
  • The model aids in identifying the number of distinct active enzyme forms during deactivation.

Conclusions:

  • The generalized unimolecular deactivation model provides a framework for analyzing enzyme stability.
  • Parameter analysis is crucial for accurate interpretation of enzyme deactivation data.
  • Exceptions to the general model include higher-order processes like dissociation and contamination.