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Updated: Jul 4, 2026

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
Published on: August 8, 2022
Novel bone substitute composed of oligomeric proanthocyanidins-crosslinked gelatin and tricalcium phosphate
Kuo-Yu Chen1, Pei-Chi Shyu, Yueh-Sheng Chen
1Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Abstract:
A biodegradable GTP composite composed of OPCs crosslinked gelatin with tricalcium phosphate was prepared as a novel bone substitute. The effects of the degree of crosslinking on the swelling ratio, in vitro degradation rate, and morphology of the GTP composite are discussed. Adding OPCs to GP and GTP composites markedly reduced the degradation rate, indicating that OPCs are good crosslinking reagents for gelatin. Cytotoxic tests demonstrated that OPCs, gelatin and tricalcium phosphate released from GTP composite promoted the proliferation of MG-63 cells. Results of this study suggest that the nontoxic GTP composite is suitable for use as a large defect bone substitute.
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