Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural specificity in coiled-coil interactions.

Gevorg Grigoryan1, Amy E Keating

  • 1MIT Department of Biology, Cambridge, MA 02139, United States.

Current Opinion in Structural Biology
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate.

bioRxiv : the preprint server for biology·2026
Same author

Beyond native sequence recovery: Improved modeling of the sequence-energy landscape of protein structures.

bioRxiv : the preprint server for biology·2026
Same author

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B.

bioRxiv : the preprint server for biology·2026
Same author

Design of Specific Peptide Inhibitors of Toxin-Antitoxin-Mediated Antiphage Defense.

ACS synthetic biology·2025
Same author

Training bias and sequence alignments shape protein-peptide docking by AlphaFold and related methods.

Protein science : a publication of the Protein Society·2025
Same author

Jointly Embedding Protein Structures and Sequences through Residue Level Alignment.

PRX life·2025
Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026
Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026
Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026
Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026
Same journal

Editorial overview: Folding, binding and protein design.

Current opinion in structural biology·2026
Same journal

Macromolecular crowding reshapes the conformational landscapes of intrinsically disordered proteins: mechanisms, cellular contexts, and functional consequences.

Current opinion in structural biology·2026
See all related articles

Novel coiled coil structures offer new insights for protein design. Large datasets and predictive scoring methods enhance understanding of coiled-coil stability and interactions, aiding future applications.

Area of Science:

  • Protein engineering and design
  • Structural biology
  • Bioinformatics

Background:

  • Coiled coils are fundamental protein structures with a long history in design and engineering.
  • Recent discoveries, like the seven-helix coiled coil, continue to reveal novel structural possibilities.
  • Understanding factors influencing coiled coil stability is crucial for protein design.

Purpose of the Study:

  • To highlight the significance of large-scale mutation datasets in coiled coil research.
  • To discuss the utility of sequence- and structure-based scoring methods for predicting interactions.
  • To explore the potential of experimental and computational approaches for coiled coil design.

Main Methods:

  • Analysis of large-scale datasets quantifying mutation effects on coiled coil stability.

Related Experiment Videos

  • Application of scoring methods (sequence and structure-based) to predict protein interactions.
  • Investigation of experimental and computational techniques for managing coiled coil structural degeneracy.

    • Main Results:

    • Large datasets provide valuable quantitative data on coiled coil stability.
    • Scoring methods demonstrate predictive power for bZIP transcription factor dimerization.
    • Promising experimental and computational strategies are emerging for coiled coil design.

    Conclusions:

    • Coiled coil research continues to yield surprising insights and novel structures.
    • Quantitative data and predictive models are advancing the field of protein design.
    • Future applications in protein design are expected to benefit from improved methods for analyzing coiled coil structures.