Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Binary Fission01:26

Binary Fission

5.5K
Binary fission is the primary mode of asexual reproduction in prokaryotes, such as bacteria. It results in the production of two genetically identical daughter cells. This highly efficient process ensures the rapid propagation of bacterial populations under favorable conditions and involves coordinated cellular and molecular events.DNA Replication and SeparationThe process begins with the replication of the bacterial chromosome. The circular DNA molecule unwinds at a specific origin of...
5.5K
Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

894
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
894
Replication in Prokaryotes01:32

Replication in Prokaryotes

29.5K
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
29.5K
Replication in Prokaryotes02:35

Replication in Prokaryotes

103.1K
Overview
103.1K
Bacterial Transformation01:33

Bacterial Transformation

63.1K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
63.1K
Bacterial Transformation01:33

Bacterial Transformation

14.2K
No description available
14.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning-enabled discovery of antibiotics effective against <i>Neisseria gonorrhoeae</i>.

Science translational medicine·2026
Same author

Generative AI for synthetic biology: Designing biological parts, circuits, and genomes.

Cell systems·2026
Same author

FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling.

Nature communications·2026
Same author

Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations.

Nature biomedical engineering·2026
Same author

Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Unusual inheritance of a functional <i>cki</i> homolog in the human pathogen <i>Schistosoma mansoni</i>.

Science advances·2025

Related Experiment Video

Updated: Mar 31, 2026

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.9K

Rewiring bacteria, two components at a time.

Michael A Kohanski1, James J Collins

  • 1Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington St., Boston, MA 02215, USA.

Cell
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

Researchers developed a method to redesign protein interactions in prokaryotic signaling systems. This advance aids in understanding protein specificity and creating synthetic signaling pathways.

More Related Videos

Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit
08:25

Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit

Published on: October 31, 2019

17.4K
Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

47.1K

Related Experiment Videos

Last Updated: Mar 31, 2026

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.9K
Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit
08:25

Genetic Modification of Cyanobacteria by Conjugation Using the CyanoGate Modular Cloning Toolkit

Published on: October 31, 2019

17.4K
Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

47.1K

Area of Science:

  • Microbiology
  • Molecular Biology
  • Systems Biology

Background:

  • Prokaryotic two-component signal transduction systems (TCS) are crucial for cellular responses.
  • Understanding the specificity of protein-protein interactions in TCS is vital for biological control.

Discussion:

  • Skerker et al. (2008) introduce a rational engineering approach to modify TCS.
  • This method allows for the rewiring of protein-protein interactions and output functions.
  • The study focuses on prokaryotic systems, offering a model for broader applications.

Key Insights:

  • A systematic method for altering protein interactions in TCS has been established.
  • The research provides a framework for dissecting and manipulating signal transduction pathways.
  • Demonstrates the feasibility of rationally designing synthetic signaling cascades.

Outlook:

  • Potential for engineering novel biological functions through synthetic signaling.
  • Implications for developing biosensors and controlling cellular behavior.
  • Further research can explore applying this method to more complex signaling networks.