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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jul 4, 2026

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Minireview: stem cell contribution to ovarian development, function, and disease.

Jonathan L Tilly1, Bo R Rueda

  • 1Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA. jtilly@partners.org

Endocrinology
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

Stem cells in the ovary are crucial for both germline and somatic functions. Recent research highlights their role in normal ovarian function and potential links to diseases like ovarian cancer.

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Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
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Last Updated: Jul 4, 2026

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays
08:39

Evaluation of Stem Cell Properties in Human Ovarian Carcinoma Cells Using Multi and Single Cell-based Spheres Assays

Published on: January 3, 2015

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

Area of Science:

  • Reproductive Biology
  • Stem Cell Science
  • Ovarian Physiology

Background:

  • Oocytes are known for their role in reproduction and reprogramming somatic cells.
  • Historically, stem cell research in ovaries focused on the germline.
  • Emerging evidence suggests somatic stem cells are vital for ovarian function.

Purpose of the Study:

  • To explore the relevance of stem cells in normal ovarian function.
  • To investigate the potential role of stem cell dysfunction in ovarian diseases.
  • To stimulate research on stem cells in mammalian female gonad physiology and pathology.

Main Methods:

  • Literature review of recent studies on ovarian stem cells.
  • Analysis of the role of germline and somatic stem cells.
  • Exploration of stem cell dysfunction in relation to ovarian pathologies.

Main Results:

  • Somatic stem cells are increasingly recognized for their importance in ovarian biology.
  • Stem cell dysfunction is implicated in conditions such as polycystic ovary syndrome and ovarian cancer.
  • Further research is needed to fully elucidate the role of stem cells.

Conclusions:

  • Stem cells, both germline and somatic, play significant roles in ovarian physiology.
  • Understanding stem cell function and dysfunction is critical for addressing ovarian diseases.
  • This review aims to guide future research directions in ovarian stem cell biology.