Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MPIDB: the microbial protein interaction database.

Johannes Goll1, Seesandra V Rajagopala, Shen C Shiau

  • 1The J. Craig Venter Institute, Rockville, MD 20850, USA. jgoll@jcvi.org

Bioinformatics (Oxford, England)
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A quantitative metabolic signature of host response during SARS-CoV-2 infection and recovery.

iScience·2026
Same author

Esophageal epithelial cell-state transitions underlie the severity of pediatric eosinophilic esophagitis.

bioRxiv : the preprint server for biology·2026
Same author

Satellite assessment of winter cover crop and conservation tillage outcomes to support adaptive management in working landscapes.

Journal of environmental quality·2025
Same author

Microbiome signatures and their role in uveitis: Pathogenesis, diagnostics, and therapeutic perspectives.

Progress in retinal and eye research·2025
Same author

Impact of donor human milk pasteurization methods on the gut microbiome of preterm infants.

Pediatric research·2025
Same author

Idiopathic Subglottic Stenosis and the Epithelial Interface of Host and Environment.

Journal of the American College of Surgeons·2025
Same journal

MCFST: Spatial domain identification method based on multi-view graph convolutional network and graph fusion network.

Bioinformatics (Oxford, England)·2026
Same journal

SpaBiT: Enhancing Spatial Transcriptomics Resolution via Bidirectional Attention Transformers.

Bioinformatics (Oxford, England)·2026
Same journal

EDEL: Enhancing Dense Retrievers for Curation of Biomedical Knowledge Bases.

Bioinformatics (Oxford, England)·2026
Same journal

Informative Relational Learning for Adverse Reaction Prediction with Enhanced Generalization to Novel Drugs.

Bioinformatics (Oxford, England)·2026
Same journal

An interpretable deep learning framework uncovers features governing CRISPR-Cas9 genome-editing efficiency.

Bioinformatics (Oxford, England)·2026
Same journal

3DICE: Interpretable 3D Cross-Modal Learning for Drug-Target Interaction Prediction and Large-Scale Drug Discovery.

Bioinformatics (Oxford, England)·2026
See all related articles

The Microbial Protein Interaction Database (MPIDB) consolidates known physical microbial protein interactions. It offers 22,530 curated interactions from 191 bacterial species, supported by extensive experimental and computational evidence.

Area of Science:

  • Microbiology
  • Bioinformatics
  • Systems Biology

Background:

  • Microbial protein interactions are crucial for understanding bacterial cellular processes.
  • Existing databases lack comprehensive coverage and diverse evidence types for microbial interactions.

Purpose of the Study:

  • To establish a centralized repository for physical microbial protein interactions.
  • To provide a comprehensive and well-supported resource for researchers.

Main Methods:

  • Manual curation of literature data.
  • Integration of data from existing protein interaction databases (IntAct, DIP, BIND, MINT).
  • Inclusion of supporting evidence from interaction conservation, co-purification, and 3D domain contacts (iPfam, 3did).

Related Experiment Videos

Main Results:

  • The Microbial Protein Interaction Database (MPIDB) contains 22,530 experimentally determined interactions.
  • These interactions involve proteins from 191 bacterial species/strains.
  • Data is supported by 24,060 experimental evidences and 8,150 additional computational/inferred evidences.

Conclusions:

  • MPIDB serves as a valuable resource for exploring microbial protein-protein interactions.
  • The database enhances understanding of bacterial biology through curated and diverse interaction data.
  • MPIDB facilitates further research in microbial systems biology and drug discovery.