Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vagolysis.

C D Hutchinson1, D L Jardine, M Hurrell

  • 1Canterbury District Health Board, Christchurch, New Zealand. Christopher.Hutchinson@cdhb.govt.nz

Age and Ageing
|June 17, 2008
PubMed
Summary
This summary is machine-generated.

A rare case of baroreflex failure caused by radiotherapy-induced nerve damage is presented. This condition, marked by fluctuating blood pressure, should be considered in patients with a history of neck radiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomised controlled trial evaluating the effects of intraoperative computed tomography on the outcomes of zygomatic fractures.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2026
Same author

Progressive baroreflex dysfunction and hypotension preceding VVS: a vicious cycle?

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2025
Same author

Mesenteric blood flow and muscle sympathetic nerve activity during vasovagal syncope.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2024
Same author

Predicting medical students who will have difficulty during their clinical training.

BMC medical education·2017
Same author

Adverse drug events are a major cause of acute medical admission.

Internal medicine journal·2014
Same author

At the heart of the arterial baroreflex: a physiological basis for a new classification of carotid sinus hypersensitivity.

Journal of internal medicine·2013
Same journal

Overall and cause-specific mortality and associated risk factors among middle-aged and older South Africans: findings from the health and ageing in Africa: a longitudinal study of an INDEPTH community in rural South Africa (HAALSI).

Age and ageing·2026
Same journal

Effect of antihypertensive medication reduction on short-term blood pressure control in older adults: calibration of OPTiMISE trial results to real-world primary care data.

Age and ageing·2026
Same journal

New horizons in advance care planning: narratives, identity and cultural humility.

Age and ageing·2026
Same journal

Effects of a home-based exercise and physical activity intervention after inpatient rehabilitation on real-world mobility in older adults with cognitive impairment: a secondary analysis of a randomised controlled trial.

Age and ageing·2026
Same journal

The effect of Digital Inclusion for Active Living (DIAL) program for community-dwelling older adults on loneliness and social isolation: a quasi-experimental study.

Age and ageing·2026
Same journal

Geriatric team support in the emergency department-a randomised trial investigating the effects on hospital admission and community care in older adults (GerED-21).

Age and ageing·2026
See all related articles

Area of Science:

  • Neurology
  • Cardiology
  • Oncology

Background:

  • A 75-year-old male patient with a history of squamous cell carcinoma of the external auditory canal, treated with radiotherapy, presented with complex autonomic dysfunction.
  • Symptoms included labile hypertension and symptomatic postural hypotension, suggesting a disruption of blood pressure regulation.

Observation:

  • Autonomic testing, including muscle sympathetic nerve activity (MSNA), heart rate (HR), and blood pressure (BP) responses, revealed significant baroreflex failure.
  • Magnetic resonance imaging (MRI) showed scarring and a potential tumor recurrence in the external auditory canal.

Findings:

  • Urinary catecholamine levels were found to be in the high normal range.
  • The observed baroreflex failure is postulated to result from vagal and glossopharyngeal nerve damage secondary to radiotherapy and tumor recurrence.

Related Experiment Videos

Implications:

  • This rare diagnosis of baroreflex failure should be considered in patients presenting with labile hypertension, particularly those with a history of neck radiotherapy.
  • Differential diagnoses include pure autonomic failure and phaeochromocytoma, especially when catecholamine levels are high-normal.