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Prospective hospital based study on persistent diarrhoea

P Dutta1, M Lahiri, D Sen

  • 1Department of Clinical Medicine, National Institute of Cholera and Enteric Diseases, Calcutta, India.

Gut
|July 1, 1991
PubMed

Insights

Persistent diarrhea affects 12.5% of young children, with increased risk in infants aged 7-18 months and those with malnutrition. Key pathogens include Shigella and Salmonella.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Acute diarrhea and dysentery are common childhood illnesses.
  • Persistent diarrhea poses a significant health risk to young children.

Purpose of the Study:

  • To determine the incidence of persistent diarrhea in children under 5 years old.
  • To identify risk factors and associated pathogens for persistent diarrhea.

Main Methods:

  • A hospital-based study of 383 children under 5 years with acute watery diarrhea or dysentery.
  • Defined persistent diarrhea as lasting 14 days or more.
  • Analyzed demographic, nutritional, clinical, and microbiological data.

Main Results:

  • 12.5% of children experienced persistent diarrhea (≥14 days).
  • Increased incidence of persistent diarrhea was observed in children aged 7-18 months.
  • Grade II-IV malnutrition was prevalent (70.8%) in persistent diarrhea cases.
  • Shigella flexneri, Shigella dysenteriae 1, and Salmonella typhimurium were more frequently isolated in persistent diarrhea cases.
  • No correlation found between disease severity at admission, measles, and persistent diarrhea.
  • Breastfeeding was associated with a lower risk of persistent diarrhea.

Conclusions:

  • Persistent diarrhea is a significant complication in young children, particularly those aged 7-18 months and with malnutrition.
  • Specific bacterial pathogens are associated with persistent diarrhea.
  • Breastfeeding appears to be protective against persistent diarrhea.

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