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Updated: Jul 4, 2026

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

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Prosthetic vascular conduit in contaminated fields: a new technology to decrease ePTFE infections.

Peter E Fischer¹, Timothy C Fabian, Waldemar G deRijk

¹College of Medicine, Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

The American Surgeon

|June 18, 2008

Summary

This summary is machine-generated.

This study shows that minocycline and rifampin bound to ePTFE grafts resist infection from Staph aureus and Staph epidermidis for up to two weeks, offering a promising solution for vascular reconstruction.

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Area of Science:

Biomaterials Science
Infectious Disease Research
Vascular Surgery

Background:

Vascular reconstruction in contaminated settings risks infection and graft failure.
Prosthetic graft infections can lead to severe complications, including amputation.

Purpose of the Study:

To evaluate minocycline and rifampin bound to ePTFE grafts for infection resistance.
To assess controlled antibiotic elution from methacrylate-bound grafts.

Main Methods:

Kirby Bauer susceptibility testing with Staph aureus (SA) and Staph epidermidis (SE).
Antibiotic-coated (ABX) grafts tested in vitro with water bath and pulsatile flow.
High-performance liquid chromatography with mass spectroscopy (HPLC-MS) for elution analysis.

Main Results:

ABX grafts demonstrated significant zones of inhibition (ZIH) against SA (35 mm) and SE (44 mm).
After 1 week, ZIH remained substantial (23 mm for both bacteria).
HPLC-MS showed 50% antibiotic retention at 24 hours with sustained elution for 7 days.

Conclusions:

Methacrylate technology effectively binds minocycline and rifampin to ePTFE grafts.
These antibiotic-eluting grafts provide in vitro resistance to SA and SE for up to two weeks.
This approach may reduce infection rates in vascular reconstructions.