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Hyperhidrosis: what is it and why does it occur?

Yaron Shargall1, Ernie Spratt, Robert A Zeldin

  • 1Division of Thoracic Surgery, St. Joseph's Health Centre, SSW-1, 30 The Queensway, Toronto, ON M6R 1B5, Canada.

Thoracic Surgery Clinics
|June 19, 2008
PubMed
Summary
This summary is machine-generated.

Hyperhidrosis, or excessive sweating, is linked to the sympathetic nervous system. Research suggests a central abnormality in the hypothalamus may control this condition affecting palms, axillae, and soles.

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Area of Science:

  • Medical Science
  • Physiology
  • Neurology

Background:

  • Hyperhidrosis is defined as excessive sweating beyond physiological needs, triggered by heat or emotions.
  • This condition has historical documentation spanning centuries.
  • It is categorized as primary or secondary based on its underlying cause.

Purpose of the Study:

  • To explore the physiological mechanisms behind hyperhidrosis.
  • To investigate the role of the nervous system in excessive sweating.
  • To examine the potential central origin of primary hyperhidrosis.

Main Methods:

  • Literature review of historical and scientific texts on hyperhidrosis.
  • Analysis of the autonomic nervous system's role in thermoregulation and sweating.
  • Review of etiological classifications (primary vs. secondary).

Main Results:

  • Excessive sweating mechanisms are primarily associated with the sympathetic nervous system.
  • Evidence suggests a potential central nervous system abnormality.
  • A distinct hypothalamic sweat center controlling specific body areas may be involved in hyperhidrosis.

Conclusions:

  • The sympathetic nervous system is central to hyperhidrosis pathophysiology.
  • Primary hyperhidrosis may stem from a distinct abnormality within the central nervous system.
  • Further research into the hypothalamic sweat center is warranted.