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Quantitative and real-time detection of secretion of chemical messengers from individual platelets

Shencheng Ge1, Nathan J Wittenberg, Christy L Haynes

  • 1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Biochemistry
|June 19, 2008
PubMed

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...