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A single nucleotide polymorphism in the Mdm2 promoter and risk of sepsis

David A Kleiman1, Jacqueline E Calvano, Susette M Coyle

  • 1Division of Surgical Sciences, Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

American Journal of Surgery
|June 19, 2008
PubMed
Abstract

Insights

The Mdm2-SNP309(G) allele may be linked to longer hospital stays in critically ill patients. However, this genetic variation does not appear to affect other clinical outcomes or predict patient prognosis.

Area of Science:

  • Genetics
  • Molecular Biology
  • Critical Care Medicine

Background:

  • The Mdm2-SNP309(T/G) polymorphism influences Mdm2 gene transcription and the p53 pathway.
  • The impact of this polymorphism on acute illness response in humans is not well-documented.

Purpose of the Study:

  • To investigate the association between the Mdm2-SNP309 genotype and clinical outcomes in surgical intensive care unit patients.
  • To determine if Mdm2-SNP309 genotype can predict clinical outcomes in acute illness.

Main Methods:

  • Prospective enrollment of patients from a surgical intensive care unit.
  • Determination of Mdm2-SNP309 genotype (T/T, T/G, G/G).
  • Comparison of clinical outcomes based on genotype.

Main Results:

  • Eighty-five patients were analyzed: 41 with wild-type (T/T) and 44 with mutant (T/G or G/G) genotypes.
  • Patients with the mutant genotype showed a trend towards longer length of stay (LOS) in the ICU and hospital, though not statistically significant.
  • No significant genotype-based differences were observed in other clinical parameters.

Conclusions:

  • The Mdm2-SNP309(G) allele may be associated with an increased length of stay.
  • This polymorphism does not appear to influence other clinical characteristics or serve as a predictor of clinical outcome in this patient cohort.

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