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[Gastrointestinal amyloidosis].

A Lévy, M Lender

    La Nouvelle Presse Medicale
    |September 25, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Amyloidosis of the alimentary tract presents diverse forms, including primary, secondary, and heredo-familial types. Rectal biopsy is highlighted as a valuable diagnostic tool for gastrointestinal amyloidosis.

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    Area of Science:

    • Gastroenterology
    • Nephrology
    • Genetics

    Context:

    • Amyloidosis, a condition involving protein buildup, can affect the alimentary tract.
    • Understanding the varied etiologies and clinical manifestations is crucial for patient management.
    • Familial Mediterranean Fever is a significant associated condition in heredo-familial amyloidosis.

    Purpose:

    • To report on a series of 29 cases of amyloidosis affecting the alimentary tract.
    • To analyze the different types, diagnostic methods, clinical complications, and outcomes.
    • To emphasize the diagnostic utility of rectal biopsy in gastrointestinal amyloidosis.

    Summary:

    • The study analyzed 29 cases of alimentary tract amyloidosis: 17% primary, 48% secondary to other diseases, and 35% heredo-familial (linked to Familial Mediterranean Fever).

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  • Diagnosis was confirmed via biopsy in 79% of patients; gastrointestinal complications included diarrhea, malabsorption, ileus, and bleeding.
  • Renal involvement, such as proteinuria and nephrotic syndrome, was common, with terminal renal failure observed in 11 patients. Survival varied, with some patients living up to 19 years post-diagnosis.

    • Impact:

    • Highlights the diverse clinical presentations and complications of alimentary tract amyloidosis.
    • Underscores the importance of biopsy, particularly rectal biopsy, for accurate diagnosis.
    • Provides insights into patient survival and the significant impact of renal complications.