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Updated: Jul 4, 2026
05:51
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
[Neonatal tumours and congenital malformations]
O Berbel Tornero1, J A Ortega García, J Ferrís i Tortajada
1Unidad de Salud Medioambiental Pediátrica, Hospital Materno-Infantil Universitario La Fe, Valencia, España. oberbel@ono.com
Anales De Pediatria (Barcelona, Spain : 2003)
|June 19, 2008
Summary
Neonatal tumors are frequently linked to congenital abnormalities, occurring in 20.8% of cases. Understanding these associations may reveal prenatal risk factors for pediatric cancers.
Area of Science:
- Pediatric Oncology
- Neonatal Medicine
- Clinical Genetics
Context:
- The association between pediatric cancers and congenital abnormalities is established.
- However, specific data regarding the neonatal period and underlying mechanisms remain scarce.
- This study addresses the gap in understanding neonatal tumors and their link to birth defects.
Purpose:
- To determine the frequency of neonatal tumors associated with congenital abnormalities.
- To explore potential etiopathogenic hypotheses for the observed associations.
- To provide insights into the relationship between congenital anomalies and neonatal neoplasms.
Summary:
- A historical series of 72 neonatal tumors revealed that 15 cases (20.8%) had associated congenital abnormalities, diseases, or syndromes.
- Specific associations included angiomas, neuroblastomas, teratomas, central nervous system tumors, heart tumors, leukemia, kidney tumors, and adrenocortical tumors with various malformations.
- A systematic review indicated a prevalence of 15-31.6% for congenital abnormalities in neonatal tumors, with hypotheses pointing to prenatal exposure to mutagenic/carcinogenic factors.
Impact:
- Neonatal tumors exhibit a higher association with congenital abnormalities compared to other pediatric cancers.
- Standardized classification criteria are needed for better understanding.
- Investigating environmental and constitutional risk factors is crucial for advancing knowledge and prevention strategies.
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