Related Experiment Video

Updated: Jul 4, 2026

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
06:29

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells

Published on: July 30, 2020

Aurora A: target invalidated?

Andrea G Cochran1

  • 1Department of Protein Engineering, Genentech Inc, South San Francisco, CA 94080, USA. andrea@gene.com

Chemistry & Biology
|June 19, 2008
PubMed

Insights

Aurora kinases regulate cell division and are cancer drug targets. New research supports Aurora B as the superior target for cancer therapies, advancing drug development strategies.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Aurora kinases are crucial regulators of mitosis.
  • Aurora kinase inhibitors are being developed as anti-cancer agents.
  • The optimal Aurora kinase target for cancer therapy remains debated.

Purpose of the Study:

  • To evaluate the potential of Aurora kinases as drug targets in cancer treatment.
  • To provide evidence supporting Aurora B as a preferred target over other Aurora kinases.

Main Methods:

  • The study likely involved molecular and cellular assays to assess Aurora kinase function.
  • Investigated the role of Aurora B in mitotic regulation and cancer cell proliferation.

Main Results:

  • The findings presented in Girdler et al. (2008) advocate for Aurora B as a key target.
  • This research contributes evidence to the ongoing discussion regarding Aurora kinase inhibition strategies.

Conclusions:

  • Aurora B kinase inhibition shows significant promise for cancer treatment.
  • Further research into Aurora B targeted therapies is warranted based on these findings.

More Related Videos

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster11:47

A 100 KW Class Applied-field Magnetoplasmadynamic Thruster

Published on: December 22, 2018

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments06:40

Automated Delivery of Microfabricated Targets for Intense Laser Irradiation Experiments

Published on: January 28, 2021

Related Concept Videos

Radial System Protection01:23

Radial System Protection

Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
Errors in Global Positioning System01:26

Errors in Global Positioning System

Global Positioning System (GPS) technology has revolutionized navigation and positioning, but its accuracy is often compromised by various errors. These errors, stemming from environmental, satellite, and receiver-related factors, require careful mitigation to ensure reliable performance across applications.Atmospheric ErrorsGPS signals travel through the Earth’s ionosphere and troposphere, introducing delays which affect accuracy. The ionosphere is strongly influenced by charged particles,...
Potential Due to a Polarized Object01:29

Potential Due to a Polarized Object

A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
Potential Due to a Magnetized Object01:24

Potential Due to a Magnetized Object

Magnetic dipoles in magnetic materials are aligned when placed under an external magnetic field. For paramagnets and ferromagnets, dipole alignment occurs in the direction of the magnetic field. However, the dipoles align opposite to the field in the case of diamagnets. This state of magnetic polarization due to the external field is called magnetization. Magnetization is defined as the dipole moment per unit volume. It plays a similar role to polarization in electrostatics.
The vector...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Diamagnetic Shielding of Nuclei: Local Diamagnetic Current01:14

Diamagnetic Shielding of Nuclei: Local Diamagnetic Current

An applied magnetic field causes the electrons present in the molecule to circulate, setting up a local diamagnetic current within the molecule. The local diamagnetic current arising from circulating sigma-bonding electrons induces a magnetic field, Blocal that opposes the applied magnetic field, B0. The effective magnetic field experienced by these nuclei is given by the difference between the applied and local magnetic fields in a phenomenon called local diamagnetic shielding. Essentially,...