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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex

Yongjun Zhou1, Jialiang Li, Jing Zhu

  • 1Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiaotong University, Shanghai, China.

Chemistry & Biology
|June 19, 2008
PubMed
Summary

FR-008/candicidin, a heptaene macrolide antifungal, exhibits structural variations. Key enzymes KR21 and DH18 influence C-3 and C-9 modifications, impacting overall antifungal potency.

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