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Related Experiment Videos

[Low thyrotrope hormone: a new entity].

F Berthezène, J C Paffoy, A Escallier

    La Nouvelle Presse Medicale
    |October 9, 1976
    PubMed
    Summary
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    PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency.

    The Journal of clinical endocrinology and metabolism·2001

    A new syndrome, low pituitary TSH reserve, is identified using TRH stimulation and plasma iodide tests. This condition, seen in acromegaly and diabetes, indicates a transient state of thyrotropin function.

    Area of Science:

    • Endocrinology
    • Thyroid Function Testing
    • Pituitary Physiology

    Background:

    • Thyrotropin (TSH) regulation is crucial for thyroid health.
    • Assessing TSH reserve is important for diagnosing pituitary and thyroid disorders.
    • Existing tests may not fully capture subtle changes in TSH function.

    Purpose of the Study:

    • To characterize a novel syndrome termed 'low pituitary TSH reserve'.
    • To evaluate the diagnostic utility of combining TRH stimulation with plasma iodide (PII) increase tests.
    • To understand the transient nature of altered thyrotropin function.

    Main Methods:

    • Administered thyrotropin-releasing hormone (TRH) stimulation test.
    • Performed plasma iodide (PII) increase test to measure basal TSH activity.

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  • Analyzed patient cohorts with conditions like acromegaly and diabetes mellitus.

    • Main Results:

    • Identified a 'low pituitary TSH reserve' syndrome characterized by a mild or absent TRH response.
    • Patients with this syndrome were euthyroid with normal PII increase tests.
    • This state was observed in acromegaly, diabetes mellitus, and post-thyroid hormone excess or hypophysectomy.

    Conclusions:

    • The combination of TRH and PII tests can characterize low pituitary TSH reserve.
    • This syndrome represents a transient phase between normal and abnormal thyrotropin function.
    • Absence of TSH increase post-TRH is diagnostically valuable when integrated with other thyrotropin function tests.