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In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 4, 2026

Mouse Genome Engineering Using Designer Nucleases

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

Contemporary approaches for modifying the mouse genome.

David J Adams¹, Louise van der Weyden

¹Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom.

Physiological Genomics

|June 19, 2008

Summary

Mice are crucial for understanding vertebrate biology and modeling human diseases. Recent advances in mouse genetics, including new technologies and resources, accelerate gene function assessment and genetic screens.

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Last Updated: Jul 4, 2026

Mouse Genome Engineering Using Designer Nucleases

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

Area of Science:

Genetics
Developmental Biology
Genomics

Background:

Mice are a premier model organism for biological research.
Embryonic stem (ES) cell technology enables precise genome manipulation in mice.
This technology is vital for modeling human diseases and understanding gene function.

Purpose of the Study:

To review recent advancements in mouse experimental genetics.
To provide a practical guide for utilizing mouse genetic technologies.
To discuss emerging technologies and resources for genetic research in mice.

Main Methods:

Review of current literature on mouse genetics.
Description of embryonic stem (ES) cell technology.
Discussion of transposon-mediated mutagenesis and genetic screening.

Main Results:

Significant progress has been made in mouse experimental genetics.
New technologies and resources are available for researchers.
These advancements facilitate gene function assessment and genetic screens.

Conclusions:

Mouse genetics is a rapidly evolving field.
Emerging technologies will accelerate the pace of discovery.
Mice remain indispensable for advancing biological understanding and disease modeling.