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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Malignant struma ovarii.

Leila Yassa¹, Peter Sadow, Ellen Marqusee

¹Newton Wellesley Hospital, Wellesley, MA, USA.

Nature Clinical Practice. Endocrinology & Metabolism

|June 19, 2008

Summary

This summary is machine-generated.

A rare ovarian tumor, struma ovarii with papillary thyroid carcinoma, was diagnosed in a young woman. Despite the malignancy, she had no hyperthyroidism symptoms and showed no recurrence after treatment.

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Area of Science:

Gynecologic Oncology
Endocrinology
Pathology

Background:

A 25-year-old woman presented with pelvic pain and a large left ovarian mass.
Ovarian struma ovarii is a rare germ cell tumor containing mature thyroid tissue.

Observation:

Histological examination revealed a 9 cm ovarian mass with microscopic foci of papillary thyroid carcinoma.
The patient was asymptomatic for hyperthyroidism with normal thyroid function tests and serum thyroglobulin levels.

Findings:

Malignant struma ovarii was diagnosed.
Thyroid ultrasonography identified a benign thyroid nodule.
Treatment involved thyroxine to suppress TSH (thyroid-stimulating hormone).

Implications:

This case highlights the importance of considering thyroid malignancy in struma ovarii, even with normal thyroid function.
Effective management includes TSH suppression and monitoring for recurrence.
Further research into the molecular mechanisms and optimal treatment strategies for malignant struma ovarii is warranted.