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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...

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Related Experiment Video

Updated: Jul 4, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

[Hepatitis B surface antigen terminates codon bias selection].

Jun Qiang Li¹, Jing Hua Tian, Feng Liu

¹Hepatology Institute, Peking University People's Hospital, Beijing, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences

|June 19, 2008

Summary

Hepatitis B surface antigen (HBsAg) termination codon bias exists, with TAA being more common than TGA. This bias may influence RNA structure and protein function during evolution.

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A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

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Published on: February 28, 2019

Area of Science:

Molecular Biology
Virology
Genetics

Context:

Hepatitis B virus (HBV) infection is a global health concern.
Understanding HBV genetic variations is crucial for therapeutic strategies.
Termination codon usage in viral genes can impact protein expression and function.

Purpose:

To investigate the existence and conditions of termination codon bias in the hepatitis B surface antigen (HBsAg) gene.
To analyze the relationship between HBsAg termination codon usage, RNA secondary structure, and protein sequence.

Summary:

Analysis of 174 HBV reference sequences revealed two types of HBsAg termination codons: TAA (71.26%) and TGA (28.74%).
Evidence of codon bias selection was observed at the HBsAg termination codon.
This bias was found to influence RNA secondary structure and the amino acid sequence encoding the HBsAg protein.

Impact:

The findings suggest that HBsAg termination codon bias is a real phenomenon.
This bias may play a role in maintaining RNA structure and conserving protein function during HBV evolution.
Further research could explore the implications of this bias for HBV pathogenesis and treatment.