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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
Alternative promoters influence alternative splicing at the genomic level
Dedong Xin1, Landian Hu, Xiangyin Kong
1Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Plos One
|June 19, 2008
Summary
Alternative promoters are linked to alternative splicing in genes. Genes with multiple alternative promoters exhibit more alternative splicing, suggesting a coordinated role in gene expression regulation.
Area of Science:
- Genomics
- Molecular Biology
- Gene Regulation
Background:
- Transcription and mRNA processing are coupled events.
- Promoter and transcription rates impact alternative splicing.
- The biological roles of numerous alternative promoters remain unclear.
Purpose of the Study:
- To investigate the functional correlation between alternative promoters and alternative splicing.
- To analyze this relationship across human and mouse genomes.
Main Methods:
- Genome-wide analysis of human and mouse genes.
- Construction of a dataset with alternative promoter and splicing annotations.
Main Results:
- Genes with alternative promoters show increased alternative splicing compared to single-promoter genes.
- A higher number of alternative promoters correlates with more alternative splicing variants.
- Transcripts from different alternative promoters exhibit distinct splicing patterns.
Conclusions:
- Alternative promoters are positively correlated with alternative splicing at the genomic level.
- This suggests a coordinated mechanism in gene expression regulation.
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