Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world management and outcome of patients with pancreatic adenocarcinoma. Results of the Spanish RETUD gastrointestinal registry.

ESMO real world data and digital oncology·2026
Same author

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial.

British journal of haematology·2025
Same author

Systemic anticancer therapy near the end of life: an analysis of factors influencing treatment in advanced cancer patients.

ESMO open·2025
Same author

The spatial extent and the dispersal strategy of species shape the occupancy frequency distribution of stream insect assemblages.

Ecology and evolution·2024
Same author

Large shallow lake response to anthropogenic stressors and climate change: Missing macroinvertebrate recovery after oligotrophication (Lake Balaton, East-Central Europe).

The Science of the total environment·2024
Same author

Drought conditions, aridity and forest structure control the responses of Iberian holm oak woodlands to extreme droughts: A large-scale remote-sensing exploration in eastern Spain.

The Science of the total environment·2023

Related Experiment Video

Updated: Jul 4, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

[Systemic mastocytosis: systematic review].

M J Molina-Garrido1, A Mora, C Guillén-Ponce

  • 1Servicio de Oncología Médica, Hospital General Universitario de Elche, Alicante, Spain. mjmolinagarrido@hotmail.com

Anales De Medicina Interna (Madrid, Spain : 1984)
|June 19, 2008
PubMed
Summary
This summary is machine-generated.

Mastocytosis is a rare blood cancer involving abnormal mast cell growth. Treatments include chemotherapy for tumor reduction and antihistamines for symptoms, with interferon also being effective.

More Related Videos

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
07:32

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Related Experiment Videos

Last Updated: Jul 4, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
07:32

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

  • Hematology
  • Oncology

Background:

  • Mastocytosis is a hematologic malignancy defined by aberrant mast cell proliferation.
  • Classification distinguishes between cutaneous and systemic forms, with systemic disease often involving bone marrow and liver.
  • Clinical manifestations include skin lesions and systemic symptoms driven by mediator release from neoplastic mast cells.

Purpose of the Study:

  • To summarize the understanding of mastocytosis, including its classification, symptoms, and treatment options.

Main Methods:

  • Review of existing literature and consensus classifications for mastocytosis.
  • Description of common clinical presentations and pathological features.

Main Results:

  • Systemic mastocytosis frequently involves bone marrow (70%) and hepatomegaly (50%).
  • Chemotherapy is utilized to decrease tumor burden, while antihistamines manage systemic symptoms.
  • Interferon shows efficacy in both systemic and local manifestations, often preceded by prednisone therapy.

Conclusions:

  • Mastocytosis requires a multi-faceted treatment approach.
  • Management strategies target both the underlying malignancy and the symptomatic effects of mediator release.