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Infratentorial progressive multifocal leucoencephalopathy (PML) in a patient with SLE (2008: 4b)

Per-Ake Svensson1, Elna-Marie Larsson

  • 1Department of Diagnostic Radiology, University Hospital, SE-221 85, Lund, Sweden.

European Radiology
|June 19, 2008
PubMed

Insights

Progressive multifocal leukoencephalopathy (PML) typically affects the brain's white matter. This case highlights PML can also present with lesions in the cerebellum and brain stem in immunocompromised individuals.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease affecting immunocompromised patients.
  • Typical magnetic resonance imaging (MRI) findings include supratentorial white matter lesions.

Observation:

  • A case of PML presented with selective infratentorial involvement.
  • Lesions were observed in the cerebellum and brain stem.

Findings:

  • PML diagnosis should be considered even with isolated infratentorial lesions.
  • Asymmetric, nonenhancing white matter lesions were noted.

Implications:

  • Broadens the differential diagnosis for infratentorial lesions in immunocompromised patients.
  • Highlights the importance of considering PML beyond typical supratentorial presentations.
  • May influence diagnostic imaging protocols for suspected PML.

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