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Related Experiment Video

Updated: Jul 4, 2026

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Published on: January 3, 2011

Schistosome/mollusk: genetic compatibility.

A L D Oliveira¹, D Da Silva, E M Zanotti-Magalhaes

¹Interunidades em Biotecnologia, Universidade de São Paulo, São Paulo, SP, Brasil.

Genetics and Molecular Research : GMR

|June 19, 2008

Summary

Understanding snail genetics is key to controlling schistosomiasis. This study found significant genetic variation within snail species, offering potential targets for disease transmission disruption.

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Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Cercarial Transformation and in vitro Cultivation of Schistosoma mansoni Schistosomules

Published on: August 16, 2011

Area of Science:

* Parasitology
* Genetics
* Public Health

Background:

* Schistosomiasis is a prevalent parasitic disease with major economic and public health impacts in developing nations.
* Controlling schistosomiasis requires understanding the complex host-parasite relationship, particularly snail susceptibility and parasite development.
* Genetic factors influencing snail-parasite interactions are crucial for developing novel disease control strategies.

Purpose of the Study:

* To investigate the genetic basis of snail-parasite relationships in schistosomiasis transmission.
* To analyze genetic variability within and between susceptible and resistant snail strains.
* To identify potential genetic targets for disrupting parasite transmission.

Main Methods:

* Random Amplified Polymorphic DNA-Polymerase Chain Reaction (RAPD-PCR) was employed.
* Genetic variability was assessed within and between Biomphalaria glabrata and B. tenagophila snail species.
* Three different primers were used to analyze intrapopulational and interpopulational variations.

Main Results:

* Significant genetic variations were observed within both Biomphalaria glabrata and B. tenagophila snail species (intrapopulational variation).
* Limited individual genetic differences were found between susceptible and resistant strains within the same snail species (interpopulational variation).

Conclusions:

* Substantial genetic diversity exists within snail populations, indicating complex population structures.
* The genetic basis for susceptibility and resistance to schistosomiasis infection in these snail species warrants further investigation.
* Understanding this genetic variability may lead to new methods for controlling schistosomiasis transmission.