Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantifying the interplay effect in prostate IMRT delivery using a convolution-based method.

Haisen S Li1, Indrin J Chetty, Timothy D Solberg

  • 1Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska 68198-7521, USA. haisenli@unmc.edu

Medical Physics
|June 20, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating natural language processing into radiation oncology: a practical guide to transformer architecture and large language models.

BJR artificial intelligence·2026
Same author

Standardized reporting as a foundation for trustworthy and reproducible artificial intelligence in radiotherapy.

Physics and imaging in radiation oncology·2026
Same author

Maintaining quality of scientific peer-review and publishing in <i>Physics and Imaging in Radiation Oncology</i>.

Physics and imaging in radiation oncology·2026
Same author

Deformable Dose Mapping and Accumulation Techniques for Stereotactic Body Radiation Therapy (SBRT) of Lung Cancers.

International journal of radiation oncology, biology, physics·2026
Same author

Dose-Volume Histogram Compendium of Dose Constraints for Treatment Planning: An ASTRO Consensus Paper.

Practical radiation oncology·2026
Same author

What an RVU experiment taught me about Medical Physics.

Journal of applied clinical medical physics·2025
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

A new segment-based convolution method accurately models interplay effects in intensity modulated radiation therapy (IMRT). This approach accounts for intrafraction motion during each treatment segment, improving dose calculation accuracy for radiation oncology.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Biology

Background:

  • Intensity modulated radiation therapy (IMRT) requires precise dose delivery.
  • Organ motion during treatment delivery can significantly impact dose accuracy.
  • The interplay effect between organ motion and multileaf collimator (MLC) movement is a challenge in step-and-shoot IMRT.

Purpose of the Study:

  • To develop and evaluate a segment-based convolution method for accounting for intrafraction organ motion and MLC interplay effects in IMRT.
  • To compare the segment-based method against the conventional average-based convolution method.

Main Methods:

  • Developed a segment-based convolution method where static dose per segment is convolved with segment-specific motion probability density functions (PDFs).

Related Experiment Videos

  • Utilized intrafraction prostate motion data from 35 patients tracked with the Calypso system to generate motion PDFs.
  • Convolved motion PDFs with dose distributions from clinical prostate IMRT plans.

    • Main Results:

    • The segment-based method revealed interplay effect errors up to 25.9% in mean CTV dose for single segments compared to fraction-averaged PDFs.
    • Interplay effect reduced minimum CTV dose by 4.4% and CTV generalized equivalent uniform dose by 1.3% in single fraction plans.
    • Discrepancies in total dose due to interplay effect were negligible for entire treatment courses (hypofractionated or conventional regimens).

    Conclusions:

    • Segment-based convolution accurately accounts for intrafraction motion and interplay effects in step-and-shoot IMRT.
    • While significant for individual segments, the overall impact of interplay effects on total dose is minimal for complete treatment courses.
    • This method enhances dose calculation accuracy in IMRT, particularly for treatments sensitive to intrafraction motion.