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Related Experiment Video

Updated: Jul 4, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

[Propofol-induced hallucinations and dreams].

Virginie Marchaisseau¹, Aurélie Molia, Emmanuelle Herlem

¹Centre Régional de Pharmacovigilance, Centre Hospitalier Universitaire, Reims, France.

Therapie

|June 20, 2008

Summary

Propofol can cause postoperative hallucinations and dreams, often pleasant with sexual connotations, even at low doses. These effects are not listed in the drug's product information and warrant inclusion.

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Last Updated: Jul 4, 2026

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

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Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

Area of Science:

Anesthesiology
Pharmacovigilance

Context:

Propofol is a widely used anesthetic agent.
Current drug information lacks details on specific side effects like hallucinations and dreams.

Purpose:

To investigate and highlight the occurrence of propofol-induced hallucinations and dreams.
To assess the significance of these reported effects.

Summary:

A review of pharmacovigilance data and literature revealed that postoperative hallucinations and dreams are not uncommon with propofol.
These experiences are frequently pleasant, sometimes with sexual undertones, and may involve uninhibited behavior or expression of intimate thoughts.
Propofol appears to play a role in facilitating pleasant dreams.

Impact:

The findings suggest that propofol's Summary of Product Characteristics (SPC) should be updated to include these effects.
Inclusion in the SPC may have legal implications for healthcare providers and manufacturers.