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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

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Related Experiment Video

Updated: Jul 4, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

Murine microRNAs implicated in liver functions and aging process.

Olivier C Maes1, Jin An, Harshini Sarojini

  • 1Gheens Center on Aging & Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA.

Mechanisms of Ageing and Development
|June 20, 2008
PubMed
Summary
This summary is machine-generated.

Aging livers show increased microRNAs (miRNAs) that may impair regeneration and detoxification. These findings highlight specific miRNAs involved in mammalian aging processes.

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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Related Experiment Videos

Last Updated: Jul 4, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Area of Science:

  • Molecular Biology
  • Gerontology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs crucial for gene regulation.
  • Aging involves complex cellular and developmental changes, with miRNAs playing a role in these processes.

Purpose of the Study:

  • Investigate the role of miRNAs in mammalian liver aging.
  • Identify specific miRNAs and their targets associated with age-related liver decline.

Main Methods:

  • Assessed expression profiling of 367 murine miRNAs in mouse livers across a lifespan (4-33 months).
  • Compared miRNA targets with proteomic profiling data from the same animals.
  • Analyzed miRNA expression changes in relation to aging and liver function.

Main Results:

  • Observed gradual increases in miR-669c and miR-709 levels in mid-aged to old livers.
  • Found significant up-regulation of miR-93 and miR-214 in extremely old livers.
  • Identified no miRNAs showing significant down-regulation with age.
  • Up-regulated miRNAs target proteins involved in detoxification, regeneration, and mitochondrial function, which decline with age.

Conclusions:

  • Key miRNAs are up-regulated in aging mouse livers.
  • These miRNAs may contribute to the age-related decline in liver regeneration and oxidative defense.
  • Target identification suggests a role for specific miRNAs in impairing detoxification pathways, including glutathione S-transferases.