Related Experiment Video
Updated: Jul 4, 2026
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Human immunodeficiency virus-induced uveitis: intraocular and plasma human immunodeficiency virus-1 RNA loads
Aniki Rothova1, Margriet Schneider, Jolanda D F de Groot-Mijnes
1Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.
Objective:
To report on a human immunodeficiency virus (HIV)-infected patient with uveitis and an intraocular HIV1 RNA load largely exceeding that of plasma and no evidence of other intraocular infectious agents causing uveitis than HIV itself.
Design:
Interventional case report.
Participant:
A 37-year-old male HIV-infected patient with uveitis and no retinal manifestations.
Methods:
Clinical and laboratory examinations including extensive intraocular fluid analyses for various pathogens and HIV-1 RNA loads in the aqueous and plasma.
Main Outcome Measures:
Results of aqueous analysis and ophthalmologic features. Correlations between the results of aqueous testing and clinical characteristics.
Results:
A 37-year-old patient presented with progressive uveitis. He was positive for HIV-1, and his HIV-1 RNA plasma load was 44,600 copies/mL. His intraocular HIV-1 RNA load was >1,900,000 copies/mL, which largely exceeded his concurrent plasma load. No evidence of infectious agents other than HIV itself was found, and the uveitis reacted promptly to solely the antiretroviral treatment.
Conclusions:
Our findings suggest that HIV can locally replicate within the eye and cause an intraocular inflammatory reaction.
