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Published on: May 16, 2022
A novel preparation method for PLGA microspheres using non-halogenated solvents.
Akihiro Matsumoto1, Takeo Kitazawa, Junichi Murata
1Tanabe Seiyaku Co. Ltd., 2-10, Dosho-machi 3-chome, Chuo-ku, Osaka 541-8505, Japan. matsumoto.akihiro@mf.mt-pharma.co.jp
Summary
Researchers developed a novel, non-halogenated solvent method for poly(lactic-co-glycolic acid) (PLGA) microsphere preparation. This technique efficiently encapsulates drugs like Vitamin B12, achieving high yields and sustained release over three weeks.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Chemical Engineering
Background:
- Traditional emulsion solvent evaporation methods often rely on halogenated solvents, posing environmental and safety concerns.
- Developing greener, non-halogenated solvent systems is crucial for sustainable pharmaceutical manufacturing.
Purpose of the Study:
- To introduce and validate a novel Oil/Water emulsion solvent evaporation method using non-halogenated solvents for poly(DL-lactic-co-glycolic acid) (PLGA) microsphere preparation.
- To optimize the process for high yield and efficient drug encapsulation.
- To evaluate the drug release profile of the prepared microspheres.
Main Methods:
- Utilized an Oil/Water emulsion solvent evaporation technique with acetone and aqueous glycerol.
- Employed poly(vinyl alcohol) as the continuous phase stabilizer.
- Investigated the effect of glycerol concentration on microsphere formation, yield, and encapsulation efficiency.
- Used Vitamin B12 as a model drug for encapsulation and release studies.
Main Results:
- Successful formation of poly(DL-lactic-co-glycolic acid) (PLGA) microspheres was achieved with glycerol concentrations above 60% in the continuous phase.
- Optimal yield and encapsulation efficiency of approximately 80% were obtained at 70% glycerol concentration.
- The prepared microspheres demonstrated sustained release of Vitamin B12 over a three-week period.
Conclusions:
- The developed non-halogenated solvent method is effective for preparing poly(DL-lactic-co-glycolic acid) (PLGA) microspheres.
- The method offers high yield, efficient drug encapsulation, and controlled drug release, making it a promising alternative for pharmaceutical applications.
- Further research can explore its applicability with various drugs and polymer systems.
