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Related Experiment Video

Updated: Jul 4, 2026

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Reducing post-traumatic anxiety by immunization.

Gil M Lewitus1, Hagit Cohen2, Michal Schwartz1

  • 1Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Brain, Behavior, and Immunity
|June 20, 2008
PubMed
Summary

Psychological stress prompts T lymphocytes to enter the brain, aiding in stress coping. Immunizing with a myelin-related peptide may treat trauma-related disorders by restoring brain function.

Related Experiment Videos

Last Updated: Jul 4, 2026

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Area of Science:

  • Neuroimmunology
  • Behavioral Neuroscience

Background:

  • T lymphocyte trafficking to organs like skin and lungs is a known defense against stress.
  • The brain's response to psychological stress and the role of immune cells within it remain incompletely understood.

Purpose of the Study:

  • To investigate T lymphocyte trafficking to the brain in response to psychological stress.
  • To explore the mechanisms and behavioral consequences of stress-induced neuroinflammation.
  • To identify potential therapeutic targets for stress-related disorders.

Main Methods:

  • Mice were exposed to a predator odor stressor.
  • T-cell infiltration into the brain, particularly the choroid plexus, was analyzed.
  • ICAM-1 expression and corticosterone levels were measured.
  • Brain-derived neurotrophic factor (BDNF) levels were assessed.
  • Mice were immunized with a central nervous system (CNS)-related peptide.

Main Results:

  • Psychological stress increased T-cell infiltration into the brain, specifically the choroid plexus, correlating with elevated ICAM-1 expression.
  • Corticosterone administration mimicked stress effects on ICAM-1.
  • Stress resilience was linked to T-cell trafficking and hippocampal BDNF levels.
  • CNS-peptide immunization reduced stress-induced anxiety and acoustic startle response, while restoring BDNF levels.

Conclusions:

  • T lymphocytes play a crucial role in the brain's response to psychological stress and in mitigating its negative behavioral effects.
  • Myelin-related peptide immunization shows promise as a therapeutic strategy for conditions like posttraumatic stress disorder (PTSD).