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Meso-Scale Particle Image Velocimetry Studies of Neurovascular Flows In Vitro

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Large-Eddy simulation of pulsatile blood flow.

Manosh C Paul¹, Md Mamun Molla, Giles Roditi

¹Department of Mechanical Engineering, University of Glasgow, Glasgow G12 8QQ, UK. m.paul@mech.gla.ac.uk

Medical Engineering & Physics

|June 20, 2008

Summary

Large-Eddy Simulation (LES) reveals how turbulent blood flow develops after arterial stenosis. Recirculation and complex flow patterns significantly contribute to turbulence, impacting cardiovascular health.

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Area of Science:

Fluid Dynamics
Biomedical Engineering
Computational Science

Background:

Arterial stenosis significantly alters blood flow dynamics.
Understanding pulsatile flow in stenotic arteries is crucial for diagnosing and treating cardiovascular diseases.
Previous models often simplified the complex transitional flow phenomena.

Purpose of the Study:

To investigate the transition to turbulence in non-additive pulsatile blood flow downstream of a 3D arterial stenosis model.
To analyze the flow physics, including velocity, pressure, vortices, and shear stress.
To assess the efficacy of Large-Eddy Simulation (LES) in modeling such complex flows.

Main Methods:

Large-Eddy Simulation (LES) of pulsatile blood flow in a 3D channel model with a biologically relevant stenosis.
Utilizing a sinusoidal non-additive pulsation at the inlet with a Reynolds number of 1200.
Detailed analysis of flow recirculation, turbulent fluctuations, and sub-grid scale contributions.

Main Results:

High levels of flow recirculation downstream of the stenosis were observed.
Complex transient blood flow patterns were identified as key contributors to turbulent fluctuations.
LES accurately predicted sub-grid scale contributions, validating its use in pulsatile flow modeling.
Detailed flow physics, including velocity, pressure, vortices, shear stress, and energy spectra, were elucidated.

Conclusions:

Flow recirculation and transient patterns are critical in generating post-stenosis turbulence.
Large-Eddy Simulation is a valuable tool for accurately modeling pulsatile blood flow in stenotic arteries.
The findings provide insights into the pathophysiology of blood flow alterations in stenosis.