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Updated: Jul 4, 2026
Three-Dimensional Reconstruction for the Whole Lung with Early Multiple Pulmonary Nodules
Published on: October 13, 2023
Quantitative investigation of solitary pulmonary nodules: dynamic contrast-enhanced MRI and histopathologic analysis
Yu Zou1, Minming Zhang, Qidong Wang
1Department of Radiology, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qinchun Rd., Hangzhou, Zhejiang Province 310003, China.
Objective:
The purposes of this study were to analyze the relation between enhancement patterns on dynamic enhanced MRI and histologic microvessel patterns of solitary pulmonary nodules (SPNs) and to address the topic of false-positive findings in differentiating SPNs with dynamic MRI.
Subjects And Methods:
Sixty-eight patients with 68 pathologically proven SPNs (diameter
Results:
The dynamic MRI values of benign SPNs were significantly lower than those of the other SPNs (p < 0.01). The enhancement ratio at the fourth minute for active inflammatory SPNs was significantly higher than that of malignant SPNs (p < 0.01). A high correlation coefficient (r = 0.87, p < 0.001) was found between steepest slope and microvessel density. With steepest slope 1.5%/s or less, benign SPNs were clearly differentiated from other SPNs. With enhancement ratio at the fourth minute 65% or less, malignant SPNs were differentiated from active inflammatory SPNs with high sensitivity (93%) and high specificity (100%).
Conclusion:
Dynamic MRI values reflect the quantitative and morphologic characteristics of microvessels in SPNs and are a useful tool for differentiating SPNs with little overlap.
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