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[Invasive disease caused by Streptococcus pneumoniae: serotypes and antimicrobial susceptibility in a Health Care

F Pardo Sánchez1, M L Pérez del Molino Bernal, P A Romero Jung

  • 1Servicio de Microbiología, Hospital Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|June 20, 2008
PubMed

Insights

This study identified the most common Streptococcus pneumoniae serotypes causing invasive diseases in Santiago de Compostela. It also revealed high resistance to erythromycin and penicillin among these bacterial isolates.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Context:

  • Invasive Streptococcus pneumoniae infections pose a significant public health challenge.
  • Understanding regional serotype distribution and antimicrobial resistance is crucial for effective treatment and prevention strategies.

Purpose:

  • To determine the predominant serotypes of Streptococcus pneumoniae causing invasive diseases in the Health Care Area of Santiago de Compostela between 2004 and 2006.
  • To assess the antimicrobial susceptibility patterns of these isolates.

Summary:

  • A total of 218 Streptococcus pneumoniae isolates from various invasive sites were analyzed.
  • Serotypes 19, 3, 1, 14, 23, and 6 were the most prevalent, accounting for over 5% of cases.
  • While 63.76% of isolates were susceptible to all tested antibiotics, significant resistance was observed for erythromycin (24.31%) and penicillin (18.34%), particularly in serotypes 19, 14, and 6. Resistance to levofloxacin and cefotaxime was low, and no vancomycin resistance was detected.

Impact:

  • This data provides valuable insights into the local epidemiology of invasive pneumococcal disease.
  • Findings can inform vaccination policies and guide empirical antibiotic treatment choices, potentially reducing morbidity and mortality.
  • Highlights the need for ongoing surveillance of antimicrobial resistance patterns in Streptococcus pneumoniae.

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