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Cell migration in the rat embryonic neocortex.

S A Bayer1, J Altman, R J Russo

  • 1Department of Biology, Indiana-Purdue University, Indianapolis 46205.

The Journal of Comparative Neurology
|May 15, 1991
PubMed
Summary
This summary is machine-generated.

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Neurons destined for the lateral neocortex migrate via a distinct pathway, the lateral cortical stream, originating medial to their final positions. This migration pattern influences neuron arrival times and is crucial for cortical development.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Biology

Background:

  • Cortical morphogenesis involves complex cell migration patterns.
  • Understanding neuronal positioning is key to deciphering brain development.

Purpose of the Study:

  • To investigate the migratory routes and timing of neurons in the developing rat neocortex.
  • To characterize the role of the lateral cortical stream in neocortical development.

Main Methods:

  • Three-dimensional reconstructions of embryonic rat neocortex (E15-E21).
  • Skandha software for 3D analysis.
  • [3H]thymidine autoradiography to trace cell origins and migration.
  • Computer analysis of nuclear orientation.

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Main Results:

  • The ventricular zone shrinks medially before lateral neuron generation.
  • Neurons migrate considerable distances medially to reach lateral cortical plate destinations.
  • A prominent lateral cortical stream pathway was identified for ventrolateral neuron migration.
  • Radial migration is used for dorsal neuron migration.
  • Migration path and distance dictate neuron arrival times in the cortical plate.
  • Cells migrating via the lateral cortical stream can accumulate in a reservoir before entering other brain regions.
  • The lateral cortical stream is associated with regions surrounding the basal ganglia.

Conclusions:

  • Neuronal migration in the developing neocortex is highly organized, utilizing specific pathways like the lateral cortical stream.
  • The timing and route of neuronal migration are critical factors in establishing the mature cortical architecture.
  • The lateral cortical stream plays a significant role in the development of specific neocortical areas and connections to the basal telencephalon.