New insights into the functions of B cells
Samuel J Balin1, Jeffrey L Platt, Marilia Cascalho
1Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Abstract:
Organ transplants between genetically different individuals elicit powerful immune responses that invariably cause rejection in the absence of immune suppression. Among the immune responses elicited by organ allografts, B-cell responses causing antibody-mediated rejection are one of the most vexing. However, recent advances in the field indicate that B cells and antibodies' contribution to immunity extends well beyond the traditional functions ascribed to antibodies. Here we review "non-humoral" functions of B cells and the implications of these functions to transplantation.
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