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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammation01:38

Inflammation

Overview
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Jul 4, 2026

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
08:41

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages

Published on: April 6, 2022

Interactions between APP secretases and inflammatory mediators.

Magdalena Sastre1, Jochen Walter, Steve M Gentleman

  • 1Division of Neuroscience and Mental Health, Imperial College London, The Hammersmith Hospital, Du cane Road, London W12 0NN, UK. m.sastre@imperial.ac.uk

Journal of Neuroinflammation
|June 20, 2008
PubMed
Summary

Inflammation is linked to Alzheimer's disease (AD). Secretases involved in amyloid precursor protein (APP) processing may be key targets for anti-inflammatory drugs to treat AD.

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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Related Experiment Videos

Last Updated: Jul 4, 2026

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
08:41

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages

Published on: April 6, 2022

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Growing evidence links inflammation to Alzheimer's disease (AD) neuropathology.
  • Activated microglia and astrocytes around neuritic plaques are observed in AD brains.
  • Inflammatory mediators are increased in the brains of AD patients.

Purpose of the Study:

  • To explore the role of secretases in Alzheimer's disease (AD) inflammation.
  • To investigate the potential of secretases as targets for anti-inflammatory drugs.
  • To discuss the role of secretases in inflammation independent of amyloid-beta (Abeta) formation.

Main Methods:

  • Review of existing literature on inflammation, AD, secretases, and NSAIDs.
  • Analysis of the relationship between secretase activity and inflammatory processes.
  • Examination of how non-steroidal anti-inflammatory drugs (NSAIDs) affect amyloid precursor protein (APP) processing.

Main Results:

  • Amyloid-beta peptide (Abeta) processing by secretases is implicated in stimulating AD-related inflammation.
  • Certain NSAIDs can modulate APP processing by inhibiting beta- and gamma-secretases.
  • Inflammation may regulate the activity of secretases involved in Abeta generation.

Conclusions:

  • Secretases are crucial in regulating inflammation in Alzheimer's disease (AD).
  • Targeting secretases with anti-inflammatory drugs presents a potential therapeutic strategy for AD.
  • Further research into the role of secretases in inflammation, beyond Abeta production, is warranted.