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Related Experiment Video

Updated: Jul 4, 2026

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

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[Ergoreflex: the essence and mechanisms].

O L Vinogradova, D V Popov, o S Tarasova

Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine

|June 21, 2008

Summary

Physical loading activates the sympathetic nervous system via central command and ergoreflex. Ergoreflex, from working muscles, controls heart rate and blood pressure, especially during fatigue.

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Area of Science:

Physiology
Exercise Science
Autonomic Nervous System

Context:

Physical activity triggers sympathetic nervous system responses, including increased heart rate and blood pressure.
These responses are mediated by central command and reflexes originating from working muscles.
The ergoreflex is a key mechanism controlling cardiovascular adjustments during exercise.

Purpose:

To review the mechanisms of the ergoreflex, a reflex initiated by mechanical and metabolic changes in working muscles.
To explore how the ergoreflex adapts to conditions like hypodynamia, physical loading, and certain pathologies.
To elucidate the role of ergoreflex in sympathetic nervous system activation during physical exertion.

Summary:

Physical loading increases sympathetic activity through central command and the ergoreflex.
Ergoreflex involves mechanosensitive afferents inhibiting vagal tone and chemosensitive afferents increasing sympathetic drive.
Metabolic changes in muscles, particularly during fatigue, significantly enhance the ergoreflex's impact on blood pressure.

Impact:

Understanding the ergoreflex provides insights into cardiovascular regulation during exercise.
This knowledge is crucial for managing conditions related to autonomic dysfunction and exercise intolerance.
The review highlights the ergoreflex's adaptive capacity and its alterations in various physiological and pathological states.