Modulatory effects of Cissus quadrangularis on periodontal regeneration by bovine-derived hydroxyapatite in intrabony defects: exploratory clinical trial
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Published on: August 13, 2019
Anurag Jain1, Jaya Dixit, Dhan Prakash
1Department of Periodontics, King George's University of Dental Sciences, Lucknow, India. dranuragjain77@yahoo.co.in
Objective:
The purpose of the present study was to clinically evaluate the efficacy of bovine-derived hydroxyapatite (HA) combined with Cissus quadrangularis (CQ), as compared to bovine-derived hydroxyapatite alone in the treatment of intrabony defects.
Materials And Methods:
Twenty patients with one intrabony defect each were selected for this study. After scaling and root planing, twenty sites were randomly selected to receive either a combination of bovine-derived HA and CQ (test group) or bovine-derived HA alone (control group). Baseline and 6-month surgical reentry measurements were taken and appropriate statistical analysis was performed.
Results:
Favorable clinical results for both hard and soft tissue measurements were obtained for both groups when compared to baseline (p < 0.001), but there was no statistically significant difference for any of the measured clinical parameters between the two groups. The mean bone fill and percentage bone fill for bovine-derived HA was 2.7 +/- 0.82 mm and 63.2 +/- 17.8%, whereas for composite graft material it was 3.3 +/- 0.82 mm and 69.8 +/- 14.2%.
Conclusion:
Although composite graft material has shown a trend towards better performance, no statistically significant intergroup difference was found. Further studies are needed to establish CQ as a modulator in periodontal regenerative therapy.
