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Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

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Related Experiment Video

Updated: Jul 4, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

The Notch pathway in prostate development and cancer.

Kevin G Leong¹, Wei-Qiang Gao

¹Department of Molecular Biology, Genentech Inc., 1 DNA Way Southern San Francisco, CA 94080, USA.

Differentiation; Research in Biological Diversity

|June 21, 2008

Summary

Notch signaling is crucial for normal prostate development and maintenance. This pathway also plays a significant role in prostate cancer, acting as both an oncogene and tumor suppressor, and may mark stem cells.

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Last Updated: Jul 4, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

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Published on: February 27, 2026

Area of Science:

Molecular Biology
Cell Biology
Oncology

Background:

The Notch signaling pathway is a fundamental mechanism regulating cell fate determination in various tissues.
Recent research underscores the critical involvement of Notch signaling in prostate development and homeostasis.

Purpose of the Study:

To review the current understanding of Notch pathway elements in prostate development and tumorigenesis.
To explore the dual role of Notch pathway elements as oncogenes and tumor suppressors in prostate cancer.
To discuss the potential of Notch receptors and ligands as biomarkers for prostate stem and cancer stem cells.

Main Methods:

Literature review of studies investigating Notch pathway components in prostate biology.
Analysis of data on the function of Jagged, Delta-like, and other Notch-related families in prostate development and cancer.
Examination of evidence linking Notch signaling to prostate stem/progenitor cells and cancer stem cells.

Main Results:

Notch signaling is essential for embryonic and postnatal prostate growth, lineage specification, and adult tissue maintenance.
Notch pathway elements are implicated in the development, progression, and metastasis of prostate cancer.
Notch pathway components exhibit context-dependent roles as oncogenes or tumor suppressors in prostate tumors.

Conclusions:

The Notch pathway is a key regulator of normal prostate development and function.
Dysregulation of Notch signaling contributes to prostate tumorigenesis and progression.
Notch pathway components represent promising targets for therapeutic intervention and potential biomarkers in prostate cancer.