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Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Updated: Jul 4, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Current controversies in perinatal steroid therapy.

S Eventov-Friedman¹, E S Shinwell

¹Department of Neonatology, Kaplan Medical Center, Rehovot and Hebrew University, Jerusalem, Israel.

Acta Paediatrica (Oslo, Norway : 1992)

|June 21, 2008

Summary

Corticosteroid therapy in perinatal medicine remains controversial despite extensive research. Further investigation into optimal doses and preparations is needed for specific patient groups.

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Intratracheal Instillation of Stem Cells in Term Neonatal Rats

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Published on: May 4, 2020

Area of Science:

Perinatal medicine
Pharmacology

Background:

Corticosteroids are a controversial therapy in perinatal medicine.
Despite decades of research, significant uncertainties persist regarding their use.

Purpose of the Study:

To review the most current evidence on antenatal and postnatal corticosteroid therapy.

Main Methods:

Review of current scientific literature and clinical practice guidelines.
Analysis of evidence regarding efficacy and safety of corticosteroid use.

Main Results:

Extensive research has not resolved major uncertainties surrounding corticosteroid use.
Evidence on both antenatal and postnatal applications requires ongoing evaluation.

Conclusions:

Further research is essential to determine optimal corticosteroid doses and preparations.
Targeted investigations in specific populations are necessary to address remaining steroid issues.