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[Biological therapy treatment of juvenile idiopathic arthritis]

Troels Herlin1

  • 1Arhus Universitetshospital, Skejby, Børneafdelingen, Arhus N. t.herlin@dadlnet.dk

Ugeskrift for Laeger
|June 21, 2008
PubMed

In recent years the treatment of juvenile idiopathic arthritis (JIA) has undergone marked changes. There is substantial evidence that inhibitors of tumor necrosis factor alpha (TNFalpha) like etanercept, infliximab and adalimumab show significant efficacy when standard therapy fails, and long-term tolerability is fairly good. Patients with systemic JIA do not respond well to treatment with TNF inhibitors, but they may benefit from treatment with IL-1 and IL-6 receptor antagonists. Our knowledge is still limited regarding which patients respond to a specific biological therapy.

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