Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

1.2K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.2K
Development of the Heart01:27

Development of the Heart

2.3K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.3K
Cattell's 16 Personality Factors01:24

Cattell's 16 Personality Factors

2.4K
Raymond Cattell's trait theory offers a structured framework for understanding personality by distinguishing between two critical traits: surface and source traits. Surface traits are observable patterns of behavior, such as indecisiveness, anxiety, and irrational fears. These traits are less stable, varying across situations and over time. This means that they are less helpful in understanding the deeper aspects of an individual's personality.
In contrast, source traits are the...
2.4K
Requirements for Human Life01:26

Requirements for Human Life

13.3K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
13.3K
Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

1.6K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.6K
Energy-requiring Steps of Glycolysis01:20

Energy-requiring Steps of Glycolysis

171.4K
Glucose is the source of nearly all energy used by organisms. The first step of converting glucose into usable energy is called glycolysis. Glycolysis occurs in the cytosol of the cell over two phases: an energy-requiring phase and an energy-releasing phase. Over the first three steps, glucose is converted into different forms and attached to two phosphate groups donated by two ATP molecules, resulting in an unstable sugar. In the next two stages, the unstable sugar splits into two sugar...
171.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Signal Override: Precision Editing of Protein Kinase Cα in Heart Failure.

Circulation research·2026
Same author

RhoGEF Ect2 supports RhoA activity at cell-cell junctions through desmoplakin.

Life science alliance·2026
Same author

Publisher Correction: An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.

Nature communications·2026
Same author

Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy.

Circulation. Heart failure·2026
Same author

Correction: Cattini, P.A.; Jin, Y. Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 4421.

International journal of molecular sciences·2025
Same author

Disease penetrance and phenotypic spectrum of desmoplakin variant carriers in the population.

Heart rhythm·2025
Same journal

NCF1 aggravates cerebral ischemia-reperfusion injury by amplifying NOX2-Dependent oxidative stress and inflammatory responses.

Biochemical and biophysical research communications·2026
Same journal

Functional and structural characterization of Akkermansia muciniphila thioredoxin domain-containing protein Amuc_2173.

Biochemical and biophysical research communications·2026
Same journal

SMURF1-mediated EFEMP1 ubiquitination reverses the resistance of HCC cells to sorafenib by promoting ferroptosis.

Biochemical and biophysical research communications·2026
Same journal

Development and validation of HSP90AA1 as a risk gene in a HIF-1α pathway-related prognostic signature for hepatocellular carcinoma.

Biochemical and biophysical research communications·2026
Same journal

Quercetin suppresses TGF-β1-induced proliferation and migration of vascular smooth muscle cells via the Smad2/3/MMP-9 signaling axis.

Biochemical and biophysical research communications·2026
Same journal

Biosynthesis, characterization and biological potential of microbe-mediated silver nanoparticles using thermophilic actinomycetes, Streptomyces nigra.

Biochemical and biophysical research communications·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
10:56

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

22.0K

FGF-16 is required for embryonic heart development.

Shun Yan Lu1, Farah Sheikh, Patricia C Sheppard

  • 1Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, MB R3E3J7, Canada.

Biochemical and Biophysical Research Communications
|June 21, 2008
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor 16 (FGF-16) is essential for embryonic heart development. FGF-16 deficiency in mice leads to embryonic lethality and severe cardiac malformations by mid-gestation.

More Related Videos

Protein Isolation from the Developing Embryonic Mouse Heart Valve Region
06:55

Protein Isolation from the Developing Embryonic Mouse Heart Valve Region

Published on: September 23, 2014

9.9K
Cell Labeling and Injection in Developing Embryonic Mouse Hearts
07:20

Cell Labeling and Injection in Developing Embryonic Mouse Hearts

Published on: April 17, 2014

14.6K

Related Experiment Videos

Last Updated: Jan 26, 2026

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
10:56

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

22.0K
Protein Isolation from the Developing Embryonic Mouse Heart Valve Region
06:55

Protein Isolation from the Developing Embryonic Mouse Heart Valve Region

Published on: September 23, 2014

9.9K
Cell Labeling and Injection in Developing Embryonic Mouse Hearts
07:20

Cell Labeling and Injection in Developing Embryonic Mouse Hearts

Published on: April 17, 2014

14.6K

Area of Science:

  • Developmental Biology
  • Genetics
  • Cardiology

Background:

  • Fibroblast growth factor 16 (FGF-16) expression is observed in the embryonic mouse heart.
  • Previous studies suggest FGF-16 promotes embryonic myocardial cell growth.

Purpose of the Study:

  • To investigate the role of FGF-16 in embryonic heart development.
  • To characterize the consequences of FGF-16 deficiency in mice.

Main Methods:

  • Generation of FGF-16 knockout mice by targeting the Fgf16 locus on the X chromosome.
  • Morphological and developmental analysis of null embryos.

Main Results:

  • FGF-16 null embryos exhibited embryonic lethality by E11.5.
  • Cardiac defects observed included chamber dilation, thinned walls, and poor trabeculation.
  • External abnormalities such as hemorrhage and facial defects were noted.

Conclusions:

  • FGF-16 is crucial for embryonic heart development during mid-gestation.
  • FGF-16 positively influences myocardial growth, and its absence results in severe cardiac defects and embryonic demise.