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The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
[Neurological damage of brain tumor therapy]
D Ricard1, T De Greslan, C Soussain
1Service de neurologie, HIA du Val-de-grâce, 74, boulevard Port-Royal, 75005 Paris, France. damien.ricard@m4x.org
Revue Neurologique
|June 21, 2008
Summary
Brain tumor treatments like radiation and chemotherapy can cause neurotoxicity, impacting patient quality of life. Early diagnosis and understanding genetic factors are crucial for managing this central nervous system damage.
Area of Science:
- Neuroscience
- Oncology
- Pharmacology
Context:
- Central nervous system (CNS) damage is a common side effect of brain tumor treatments, significantly affecting patient quality of life.
- Concurrent or sequential radiotherapy and chemotherapy can have synergistic neurotoxic effects.
- Emerging neurotoxicities are becoming apparent due to advancements in brain tumor management.
Purpose:
- To review the adverse effects of brain radiation and neurotoxic chemotherapy protocols (methotrexate, platin, aracytin).
- To highlight the challenge of early neurotoxicity diagnosis and the ineffectiveness of current treatments.
- To explore the role of individual sensitivity, including genetic predisposition, in neurotoxicity.
Summary:
- Neurotoxicity from brain tumor treatments can be acute or irreversible and late-occurring.
- Early diagnosis of neurotoxicity is a major challenge, as treatments are often ineffective.
- Understanding individual susceptibility, potentially linked to genetic factors, is key for developing tailored treatments.
Impact:
- Improved understanding of neurotoxicity mechanisms can lead to personalized treatment strategies.
- Focus on early diagnosis and genetic predisposition may reduce long-term neurological deficits.
- This review aims to inform clinical practice regarding the management of neurotoxicity in brain tumor patients.
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