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Posterior reversible encephalopathy syndrome during sunitinib therapy
R Cumurciuc1, L Martinez-Almoyna, C Henry
1Service de neurologie, hôpital Delafontaine, 2, rue du Dr-Delafontaine, 93200 Saint-Denis, France.
Posterior reversible encephalopathy syndrome (PRES) is a rare side effect of sunitinib, a cancer drug. Early recognition and drug withdrawal can effectively manage this condition.
Area of Science:
- Oncology
- Neurology
Background:
- Sunitinib is a tyrosine kinase inhibitor used to treat renal cell carcinoma with ovarian metastasis.
- Posterior reversible encephalopathy syndrome (PRES) is a neurological condition characterized by headache, seizures, and visual disturbances.
Observation:
- A case of PRES occurred in a woman treated with sunitinib for ovarian metastasis of renal cell carcinoma.
- This represents the third reported case of PRES associated with sunitinib therapy in the literature.
Findings:
- The onset of PRES varied from one week to five months across the three reported cases.
- The pathophysiology of sunitinib-induced PRES likely involves both its antiangiogenic and prohypertensive effects.
Implications:
- Physicians should be vigilant for PRES as a potential side effect of sunitinib.
- Prompt discontinuation of sunitinib and symptomatic management can effectively control PRES.
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